Necessary supplement to age gracefully but way cheaper on take a lot. Nattokinase improves circulation and helps clear the body of protein waste. I sleep so well and wake feeling fresh and youthful instead of stiff, bloated, and old lol. Hope this helps someone with gut issues - I’ve used this with New Leaf Bio Cultures Probiotic & Now Foods Dairy Digest to heal my long time gut and microbiome issues. You need a good probiotic and Protease enzyme about 12+ hours apart. Proteases break down the biofilms and the good probiotic populates to take up space in your microbiome. When using for that, you take enzymes 1-2hrs before or after eating. I use one Bio Cultures + Dairy Digest when waking up then one Bio Cultures about 12 hours later when I feel it wearing off (inflammation comes back &mood dips). The Dairy Digest might sound weird but check the ingredients. It works well as a Protease. Then I take this Nattokinase before bed. The circulation and anti-inflammatory activity is amazing while you sleep. I suspect it controls the histamine response in the morning too because I wake up with a flat belly, clear head, and no pain or inflammation in my body. Never knew it was possible but it’s been 4 months now and the results are amazing. Digestion is wonderful, stomach flat, clear head all day. Dairy Digest was better than other proteases for the morning. Bromelain & papain were too intense, hurt my stomach or made me starving. Magically the dairy digest is just right for the morning protease & New Leaf Bio Cultures is the only one of twenty probiotics that didn’t trigger overgrowth, bloat, odor, etc. Everyone’s body is different but keep experimenting. Severe gut issues can heal. I avoided surgery & antibiotics and I feel better than ever :)